Publications
Altered vertebral biomechanics in prostate cancer patients
A computational study of the effects of prostate cancer and androgen deprivation treatment on the strength and fracture risk of vertebrae in men with prostate cancer, published in the journal Bone in 2025 and available here.
Air Pollution and Osteoporosis
A review of the emerging link between airborne pollutants and bone degeneration, published in the journal Current Osteoporosis Reports in 2024 and available here.
Computational predictions of cell death risk from eddy generation
A study using computational and analytical methods to show that eddy generation is a negligible risk for cell death in bioreactor systems, published in Frontiers in Bioengineering and Biotechnology in 2024 and available here.
3D Models of the Multiple Myeloma Microenvironment
A review of advanced models that are being developed to replicate Extra Medullary Disease, whereby myeloma cells escape the bone marrow microenvironment to metastasise to other tissues, published in the journal Cancers in 2024 and available here.
Role of the osteocyte in bone metastasis
An invited review of the emerging role played by osteocytes in mediating development of metastatic nice he in breast and prostate cancer metastatic colonies, published in the Journal of Bone Oncology in 2024 and available here.
Primary cilia mediated osteocyte regulation of metastasis
A study of the crosstalk between osteocytes and cancer cells in the metastatic niche, published in Advanced Science in 2024 and available here.
In silico modelling of complex bone scaffolds
A computational study of complex geometries in bone tissue engineering scaffolds, published in Computers in Biology and Medicine in 2023 and available here.
Osteocytes and Primary Cilia
A review of the primary cilium and its mediating role in osteocyte mechanotransduction, published in Current Osteoporosis Reports in 2023 and available here.
Osteoclastogenesis Requires Primary Cilia Disassembly
A in vitro study of osteoclast primary cilia, showing that cilium disassembly is required for osteoclastogenesis, published in Cells Tissues Organs in 2023 and available here.
Organ-on-a-Chip and Microfluidic Platforms for Oncology in the UK
A review of the broad sweep of organ-chip research in the cancer research in the UK, and the network of researchers and companies being developed, published in the journal Cancers in 2023.
Disrupted osteocyte mechano-biology in aging
A study combining transcriptomics (RNAseq) and computational modelling (CFD) to investigated the role played by aging and TGF-β in osteocyte mechanosensing, published in the Proceedings of the National Academy of Sciences (PNAS) in 2021.
Mechanical Stimulation Modulates Osteocyte Regulation of Cancer Cell Phenotype
An organ-on-a-chip model of the how mechanical stimulation of osteocytes affects the phenotype of breast and prostate cancer cells, published in the journal Cancers in 2021.
Biomechanical stimulation in developmental dysplasia of the hip
A study of the link between fetal biomechanics and risk factors for DDH, published in the Journal of Biomechanics in 2018.
Book Chapter: Bone Mechanobiology in Health and Disease
This chapter describes the state-of-the-art in the study of bone mechanobiology, and was published in Mechanobiology in Health and Disease in 2018.
Book Chapter: Techniques to Study Mechanobiology
A chapter describing the multitude of methods which can be employed to answer mechanobiological research questions, published in Mechanobiology in Health and Disease in 2018.
Stresses and strains on the human fetal skeleton during development
A study of how stress and strain change over gestation, published in the Journal of the Royal Society Interface in 2018.
Failure of the fetal membrane
A study of the mechanics of fetal membrane rupture, published in PLOS ONE in 2017.
Ontogeny of the human pelvis
A review of the development of the human pelvis in individuals, published in the Anatomical Record in 2017.
In silico bone mechano-biology
A review of computational modelling in bone mechanobiology, published in the Wiley Interdisciplinary Reviews: Systems Biology & Medicine in 2016.
Mechanisms of osteocyte stimulation in osteoporosis
A study of osteocyte mechanical stimulation in osteoporosis, published in the Journal of the Mechanical Behaviour of Biomedical Materials in 2016.