On the left, a gloved hand holding a petri dish in a laboratory setting. On the right, a computer screen displaying programming code is seen through glasses sitting on a keyboard.

Our Research

Unpicking how cancer hijacks bone

The Verbruggen Lab builds complex engineered in vitro microenvironments, such as organ-on-a-chip devices, to investigate how invading cancer cells hijack normal bone cell remodelling.

Fluorescent microscopy image of cells with green, blue, and pink staining, indicating different cellular structures.

Predicting fractures in cancer patients

Using computational modelling to build digital twins from clinical scans, our team predicts the biomechanics, bone strength and fracture risk of patients who’s bones are damaged from cancer.

Spinal x-ray showing blue-green highlighted area indicating stress distribution in a vertebra with metastatic cancer.

Seeing how bone cells sense exercise

Dr. Verbruggen’s PhD research, exploring how cells sense mechanical stimuli, in healthy and osteoporotic bone.

Microscopic view of osteocytes with fluorescent staining, showing green and red interconnected lacunar-canalicular network.

Understanding maternal and foetal biomechanics

Reproductive and developmental biomechanics are poorly studied areas of research. The Verbruggen Lab works with biomedical scientist and clinical collaborators to design in silico and in vitro models that help shed light on challenging research questions in these fields.

MRI scan of fetus showing labels for hip, knee, and ankle

The Verbruggen Lab is based in…